trimethoprim

trimethoprim
A drug that inhibits the reduction of dihydrofolate to tetrahydrofolate (a later step than that inhibited by sulphonamides). Selective for some bacterial DHF reductases and often used in conjunction with sulphonamides.

Dictionary of molecular biology. 2004.

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  • Trimethoprim — Systematic (IUPAC) name …   Wikipedia

  • Trimethoprim — Strukturformel Allgemeines Freiname Trimethoprim Andere Namen …   Deutsch Wikipedia

  • trimethoprim — An antimicrobial agent that potentiates the effect of sulfonamides and sulfones; usually used in combination with sulfamethoxazole. * * * tri·meth·o·prim trī meth ə .prim n a synthetic antibacterial drug C14H18N4O3 used alone esp. to treat… …   Medical dictionary

  • trimethoprim — n. an antibacterial drug that is active against a range of microorganisms; taken by mouth, it is used mainly in the treatment of chronic urinary tract infections and respiratory tract infections. Long term treatment may cause anaemia due to… …   The new mediacal dictionary

  • Trimethoprim/sulfamethoxazole — Combination of Trimethoprim Dihydrofolate reductase inhibitor (16.7%) Sulfamethoxazole Sulfonamide antibiotic (83.3%) …   Wikipedia

  • trimethoprim-sulfamethoxazole — noun A combination of trimethoprim and sulfamethoxazole in the ratio of 1 to 5. Syn: TMP SMX, co trimoxazole …   Wiktionary

  • trimethoprim-sulfamethoxazole — A drug combination consisting of a dihydrofolate reductase inhibitor (trimethoprim) and a sulfonamide antibacterial drug (sulfamethoxazole). The drug combination is synergistic as the drugs interfere with two successive steps in the forma …   Medical dictionary

  • trimethoprim sulfate — [USP] the sulfate salt of trimethoprim, having the same actions as the base; administered topically to the conjunctiva, in combination with polymyxin B sulfate, in the treatment of ocular bacterial infections caused by susceptible organisms …   Medical dictionary

  • trimethoprim — noun Etymology: tri + meth + prim (by shortening & alteration from pyrimidine) Date: 1964 a synthetic antibacterial and antimalarial drug C14H18N4O3 used alone or in combination with sulfamethoxazole …   New Collegiate Dictionary

  • trimethoprim — /truy meth euh prim/, n. Pharm. a synthetic crystalline compound, C11H18N4O3, usually combined with a sulfonamide as an antibiotic preparation in the treatment of urinary tract infections and pneumocystis pneumonia. [1960 65; trimetho(xyphenyl) + …   Universalium

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